About Lip Clear Lysine+ Cold Sore Treatment Lip Clear Lysine+ Cold Sore ointment has been shown to reduce cold sore time by half compared to untreated cold sores. Don't let the pain and embarrassment of lingering cold sores stop you from living your life. Lip Clear Lysine+ provides fast, soothing pain relief while it moisturizes your lips and relieves burning, itching, tingling and blistering. No wonder it’s Canada’s #1 herbal/nutrient cold sore treatment. When should you use Lip Clear Lysine+ Cold Sore Treatment For best results, use at the first sign of a cold sore such as tingling, burning or itching. Apply as needed. The ointment goes on clear and relieves symptoms associated with cold sores.